Recommended

• Apache mod_expires

• TYPO3 routing configuration or TYPO3 realurl (current version >= 2.3.1) or any other speaking URL mechanism

You have to create a smart strategy to avoid editors from hitting the clear cache button all the time (more important in Boost-Mode): I suggest this UserTsConfig:

options.clearCache.pages = 0
options.clearCache.all = 0

The user could use the clear cache in the page module or the admin have to use clearCacheCmd in a smart way.

Try to avoid this configuration:

[backend.user.isLoggedIn]
    config.no_cache = 1
[global]