TYPO3 Exception 550

Note

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May happen if an extension converts a HTTP error code to an exception code.

Oops, an error occurred! Expected response code 250 but got code "550", with message "550 5.7.60 SMTP; Client does not have permissions to send as this sender

In this case, the FE_Manager tries to send a notification to the admin and the sender address or mail server information doesn't match the requirements.