TypoScript
You can disable the StaticFileCache by adding one line of TS:
config.tx_staticfilecache.disableCache = 1        
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This is also useful, if you want to disable StaticFileCache for specific page types or other conditions, for example:
[getTSFE().type == <type>]
config.tx_staticfilecache.disableCache = 1
[global]        
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